Multiple faces of pulmonary large cell neuroendocrine carcinoma: Update with a focus on practical approach to diagnosis Review

   


Authors: Baine, M. K.; Rekhtman, N.
Review Title: Multiple faces of pulmonary large cell neuroendocrine carcinoma: Update with a focus on practical approach to diagnosis
Abstract: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive malignancy that is strongly linked to smoking and notoriously difficult to diagnose and treat. Recent molecular data reveal that it represents a biologically heterogeneous group of tumors, characterized by morphologic and genomic diversity that straddles small cell and non-small cell lung carcinomas (NSCLCs), and in a minority of cases atypical carcinoids. This review provides an update on recent molecular and clinical developments in LCNEC with the main focus on practical approach to pathologic diagnosis using illustrative examples of the main differential diagnostic considerations. © Translational Lung Cancer Research. All rights reserved.
Keywords: treatment; differential diagnosis; molecular profile; large cell neuroendocrine carcinoma (lcnec)
Journal Title: Translational Lung Cancer Research
Volume: 9
Issue: 3
ISSN: 2218-6751
Publisher: Translational Lung Cancer Research  
Date Published: 2020-06-01
Start Page: 860
End Page: 878
Language: English
DOI: 10.21037/tlcr.2020.02.13
PROVIDER: scopus
PMCID: PMC7354156
PUBMED: 32676352
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090234157&doi=10.21037%2ftlcr.2020.02.13&partnerID=40&md5=29730ae489bcd94c484690b55566dbf3
Notes: Review -- Export Date: 1 October 2020 -- Source: Scopus
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MSK Authors
  1. Natasha Rekhtman
    424 Rekhtman
  2. Marina K Baine
    51 Baine
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