Pathology and diagnosis of neuroendocrine tumors: Lung neuroendocrine Journal Article
| Author: | Travis, W. D. |
| Article Title: | Pathology and diagnosis of neuroendocrine tumors: Lung neuroendocrine |
| Abstract: | Neuroendocrine (NE) tumors of the lung include a spectrum from low-grade typical carcinoid (TC) and intermediate-grade atypical carcinoid (AC) to high-grade large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). Although NE lung tumors are frequently discussed together, as in this article, carcinoids are very different from high-grade SCLC and LCNEC. SCLC and LCNEC are found in heavy-smoking, older patients, whereas smoking is not strongly associated with carcinoid tumors. On a molecular level, SCLC and LCNEC have extensive genetic abnormalities, but there are few in TC and slightly more in AC. Copyright © 2014 Elsevier Inc. All rights reserved. |
| Keywords: | review; diagnosis, differential; lung neoplasms; differential diagnosis; pathology; neuroendocrine tumor; lung tumor; lung; carcinoid; large cell carcinoma; neuroendocrine tumors; small cell carcinoma; carcinoma, small cell; large cell neuroendocrine carcinoma; neuroendocrine cell hyperplasia; neuroendocrine; carcinoma, large cell; atypical carcinoid; typical carcinoid; humans; human |
| Journal Title: | Thoracic Surgery Clinics |
| Volume: | 24 |
| Issue: | 3 |
| ISSN: | 1547-4127 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2014-08-01 |
| Start Page: | 257 |
| End Page: | 266 |
| Language: | English |
| DOI: | 10.1016/j.thorsurg.2014.04.001 |
| PUBMED: | 25065926 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 1 October 2014 -- Source: Scopus |
