Radiation-induced lung toxicity - Cellular and molecular mechanisms of pathogenesis, management, and literature review Review


Authors: Käsmann, L.; Dietrich, A.; Staab-Weijnitz, C. A.; Manapov, F.; Behr, J.; Rimner, A.; Jeremic, B.; Senan, S.; De Ruysscher, D.; Lauber, K.; Belka, C.
Review Title: Radiation-induced lung toxicity - Cellular and molecular mechanisms of pathogenesis, management, and literature review
Abstract: Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed. © 2020 The Author(s).
Journal Title: Radiation Oncology
Volume: 15
ISSN: 1748-717X
Publisher: Biomed Central Ltd  
Date Published: 2020-09-10
Start Page: 214
Language: English
DOI: 10.1186/s13014-020-01654-9
PUBMED: 32912295
PROVIDER: scopus
PMCID: PMC7488099
DOI/URL:
Notes: Review -- Source: Scopus
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  1. Andreas Rimner
    440 Rimner