Shedding light on the DNA damage checkpoint Journal Article
| Authors: | Callegari, A. J.; Kelly, T. J. |
| Article Title: | Shedding light on the DNA damage checkpoint |
| Abstract: | DNA damage checkpoint genes are required to restrain cell cycle progression during DNA repair and to maintain chromosome stability. Checkpoint mutants are highly sensitive to killing by UV light, so the responses mediated by these genes are likely to be essential for survival during exposure to solar radiation. Yet it is still unclear exactly how checkpoint responses coordinate the cell cycle with DNA repair in the presence of UV lesions. At high doses, the UV response shares features with the ionizing radiation response, such as G1/S and G2/M checkpoints. At lower doses, only a postreplication checkpoint is evident. In this perspective we attempt to reconcile these observations and address their physiological meaning, with an emphasis on insights gained from direct cell-cycle measurements and recent studies in yeast. ©2007 Landes Bioscience. |
| Keywords: | review; nonhuman; radiation dose; dna replication; ultraviolet radiation; mitosis; animals; dna damage; cell cycle; cell cycle progression; cell cycle s phase; cell division; dna repair; gene expression; protein p53; ionizing radiation; cell cycle g2 phase; yeast; ultraviolet rays; cell cycle g1 phase; checkpoint; chk1; solar radiation; ultraviolet; postreplication |
| Journal Title: | Cell Cycle |
| Volume: | 6 |
| Issue: | 6 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2007-03-15 |
| Start Page: | 660 |
| End Page: | 666 |
| Language: | English |
| PUBMED: | 17387276 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 17 November 2011" - "Source: Scopus" |
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