Cell-surface glycoproteins of human sarcomas: Differential expression in normal and malignant tissues and cultured cells Journal Article

   


Authors: Rettig, W. J.; Garin-Chesa, P.; Beresford, H. R.; Oettgen, H. F.; Melamed, M. R.; Old, L. J.
Article Title: Cell-surface glycoproteins of human sarcomas: Differential expression in normal and malignant tissues and cultured cells
Abstract: Normal differentiation and malignant transformation of human cells are characterized by specific changes in surface antigen phenotype. In the present study, we have defined six cell-surface antigens of human sarcomas and normal mesenchymal cells, by using mixed hemadsorption assays and immunochemical methods for the analysis of cultured cells and immunohistochemical staining for the analysis of normal tissues and >200 tumor specimens. Differential patterns of F19 (M(r), 120,000/95,000 glycoprotein), F24 (M(r), 95,000 glycoprotein), G171 (M(r), 75,000 glycoprotein), G253 (M(r), 90,000 glycoprotein), S5 (M(r), 120,000 glycoprotein), and Thy-1 (M(r), 25,000 glycoprotein) antigen expression were found to characterize (i) subsets of cultured sarcoma cell lines, (ii) cultured fibroblasts derived from various organs, (iii) normal resting and activated mesenchymal tissues, and (iv) sarcoma and nonmesenchymal tumor tissues. These results provide a basic surface antigenic map for cultured mesenchymal cells and mesenchymal tissues and permit the classification of human sarcomas according to their antigenic phenotypes.
Keywords: human cell; sarcoma; membrane antigen; cell culture; histochemistry; human
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 85
Issue: 9
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 1988-05-01
Start Page: 3110
End Page: 3114
Language: English
DOI: 10.1073/pnas.85.9.3110
PUBMED: 2896356
PROVIDER: scopus
PMCID: PMC280153
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0005429990&doi=10.1073%2fpnas.85.9.3110&partnerID=40&md5=65bb20708bb85c2d7df41d7bc6e79b6c
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Herbert F Oettgen
    130 Oettgen
  2. Lloyd J Old
    593 Old
  3. Pilar Garin-Chesa
    73 Garin-Chesa
  4. Wolfgang J. Rettig
    85 Rettig
  5. Myron Melamed
    148 Melamed
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