Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas Journal Article

   


Authors: Hahn, M.; Hayward, W. S.
Article Title: Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas
Abstract: We have determined the nucleotide sequences of two independent DNA clones which contained the activated c-myc genes from avian leukosis virus-induced B-cell lymphomas. Neither of these c-myc genes contained missense mutations. This strongly supports the notion that the c-myc proto-oncogene in avian leukosis virus-induced B-cell lymphomas can be oncogenically activated by altered expression of the gene without a change in the primary structure of the gene product.
Keywords: oncoprotein; genetics; mutation; proto-oncogene proteins; molecular genetics; animal; animals; proto oncogene; avian leukosis oncovirus; b lymphocyte; bird disease; avian leukosis virus; b-lymphocytes; molecular cloning; cloning, molecular; molecular sequence data; nucleotide sequence; myc protein; lymphoma; base sequence; microbiology; proto-oncogene proteins c-myc; birds; proto-oncogenes; article; avian leukosis; bird
Journal Title: Molecular and Cellular Biology
Volume: 8
Issue: 6
ISSN: 0270-7306
Publisher: American Society for Microbiology  
Date Published: 1988-06-01
Start Page: 2659
End Page: 2663
Language: English
DOI: 10.1128/mcb.8.6.2659
PUBMED: 2841585
PROVIDER: scopus
PMCID: PMC363470
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024023166&doi=10.1128%2fMCB.8.6.2659&partnerID=40&md5=126865d735c6c145665a3ceb3b47f0e9
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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  1. William Hayward
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