Ribonuclease activity is associated with subviral particles isolated from interferon-treated vesicular stomatitis virus-infected cells Journal Article

   

Authors:	Kumar, R.; Chattopadhyay, D.; Banerjee, A. K.; Sen, G. C.
Article Title:	Ribonuclease activity is associated with subviral particles isolated from interferon-treated vesicular stomatitis virus-infected cells
Abstract:	Previously we have shown that inhibition of replication of vesicular stomatitis virus in interferon-treated JLSV-11 cells is at least partly caused by impaired viral primary transcription. Here we report that subviral particles isolated from interferon-treated infected cells were deficient in mRNA synthesis in vitro compared with the particles isolated from untreated cells. This was due to the presence of an associated ribonuclease activity which hydrolyzed not only newly synthesized viral mRNAs but also exogenously added viral transcripts.
Keywords:	interferon; nonhuman; in vitro study; cell culture; ribonuclease; vesicular stomatitis virus; messenger rna synthesis
Journal Title:	Journal of Virology
Volume:	62
Issue:	2
ISSN:	0022-538X
Publisher:	American Society for Microbiology
Date Published:	1988-02-01
Start Page:	641
End Page:	643
Language:	English
DOI:	10.1128/jvi.62.2.641-643.1988
PUBMED:	2447294
PROVIDER:	scopus
PMCID:	PMC250584
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023857261&doi=10.1128%2fjvi.62.2.641-643.1988&partnerID=40&md5=1e44284627ce733cfcf29ecef7cbc6a0
Notes:	Article -- Export Date: 6 August 2020 -- Source: Scopus

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