Flow cytometry and cytology as response indicators to M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) Journal Article

  

Authors:	Hermansen, D. K.; Reuter, V. E.; Whitmore, W. F. Jr; Fair, W. R.; Melamed, M. R.
Article Title:	Flow cytometry and cytology as response indicators to M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin)
Abstract:	We evaluated 23 patients treated with neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin for muscle invasive bladder carcinoma with serial bladder wash flow cytometry and serial urinary cytology. The sensitivities of bladder wash flow cytometry and cytology in detecting bladder cancer were 74 and 47 per cent, respectively, based on subsequent diagnosis from biopsy and cystectomy specimens. Exclusion of those cases without surface carcinoma increased the sensitivities of bladder wash flow cytometry and cytology to 93 and 60 per cent, respectively. Persistently positive bladder wash flow cytometry and cytology correctly predicted residual disease in 88 and 100 per cent, respectively. However, negative bladder wash flow cytometry and cytology after chemotherapy were not reliable indicators of disease-free status.
Keywords:	clinical article; cisplatin; doxorubicin; methotrexate; flow cytometry; cytology; biopsy; vinblastine; cancer invasion; genetic engineering; bladder carcinoma; human; male; female; priority journal; bladder irrigation
Journal Title:	Journal of Urology
Volume:	140
Issue:	6
ISSN:	0022-5347
Publisher:	Elsevier Science, Inc.
Date Published:	1988-12-01
Start Page:	1394
End Page:	1396
Language:	English
DOI:	10.1016/s0022-5347(17)42053-2
PUBMED:	3193503
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024246819&doi=10.1016%2fS0022-5347%2817%2942053-2&partnerID=40&md5=14f2b01dfe3394081b63b767fe4c57ef
Notes:	Article -- Export Date: 6 August 2020 -- Source: Scopus

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