Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia Journal Article


Authors: Koo, H. B.; Sigurdson, E. R.; Daly, J. M.; Berenson, M.; Groshen, S.; Decosse, J. J.
Article Title: Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia
Abstract: Ornithine decarboxylase (ODC) activity in biopsy specimens of normalappearing rectal mucosa was measured in 15 control patients, 5 patients with colon adenomas, and 11 patients with colon cancer. While women had significantly higher ODC activity than men, ODC activity was increased regardless of gender in the rectal mucosal biopsies of patients with benign or malignant colonic neoplasia compared with those of controls. The positive predictive value of ODC activity for remote colonic neoplasia was 61 % for women and 91 % for men. The results provide a rationale for long‐term studies of ODC activity in rectal mucosa as a biological marker of high risk for large bowel neoplasia. Copyright © 1988 Wiley‐Liss, Inc., A Wiley Company
Keywords: adult; controlled study; adenoma; colon tumor; colon mucosa; ornithine decarboxylase; cancer; human; priority journal; colonic mucosa
Journal Title: Journal of Surgical Oncology
Volume: 38
Issue: 4
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 1988-08-01
Start Page: 240
End Page: 243
Language: English
DOI: 10.1002/jso.2930380407
PUBMED: 3411968
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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  1. John M. Daly
    57 Daly
  2. Susan Groshen
    28 Groshen