Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia Journal Article
| Authors: | Richter, A.; Yang, K.; Richter, F.; Lynch, H. T.; Lipkin, M. |
| Article Title: | Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia |
| Abstract: | Measurements of intermediate biomarkers have recently increased, attempting to provide useful information about cancer risk. We report morphological findings in rectal mucosal biopsies from patients at low risk and at high risk for colorectal cancer. Rectal biopsies were analyzed from fourteen Seventh-Day Adventist (SDA) subjects at low risk and from twenty-seven members of families with hereditary nonpolyposis colonic cancer (HNPCC) at higher risk. The following measurements were made on rectal crypts: length of crypts, numbers of cells, diameter of the surface, middle and base of the crypts and infiltration of inflammatory cells into the lamina propria. Findings indicated morphological differences in normal-appearing rectal mucosa of individuals in the HNPCC group compared with SDA subjects (P < 0.05). They included shorter crypts with fewer epithelial cells and increased cellular infiltration in the mucosa of HNPCC subjects compared with SDA subjects, suggesting minimal inflammation, and an early stage of crypt atrophy in the rectal mucosa of subjects at higher risk for colonic neoplasia. © 1993. |
| Keywords: | adult; controlled study; human tissue; cancer risk; united states; comparative study; colorectal cancer; cell infiltration; colonic neoplasms; risk factors; inflammatory cell; morphology; risk assessment; colon cancer; epithelium cell; cell count; familial cancer; colorectal neoplasms, hereditary nonpolyposis; normal human; rectum; intestine crypt; middle age; intestinal mucosa; rectum biopsy; lamina propria; rectum mucosa; diet, vegetarian; human; male; female; priority journal; article |
| Journal Title: | Cancer Letters |
| Volume: | 74 |
| Issue: | 1-2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 1993-10-15 |
| Start Page: | 65 |
| End Page: | 68 |
| Language: | English |
| DOI: | 10.1016/0304-3835(93)90045-b |
| PUBMED: | 8287373 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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