Synthesis of tritium‐labelled 9‐deazainosine Journal Article
| Authors: | Singh, A. K.; Klein, R. S. |
| Article Title: | Synthesis of tritium‐labelled 9‐deazainosine |
| Abstract: | The synthesis of labelled 9‐deazainosine (1a,b) from the fully blocked 9‐deazainosine (2) is achieved in six steps by selective detritylation, oxidation of the C‐5′ hydroxyl group, followed by purification via its N,N′‐diphenylimidazolidine derivative, deprotection to obtain the 5′‐aldehyde, borotritide reduction, and deisopropylidenation to give the labelled nucleoside. The sequence is of general utility in labelling nucleosides at the C‐5′ position for biochemical studies. Copyright © 1988 John Wiley & Sons, Ltd. |
| Keywords: | unclassified drug; nonhuman; antiprotozoal agent; radioisotope; synthesis; 9‐deazainosine; borotritide reduction; c‐nucleoside; tritiated nucleoside; 9 deazainosine h 3 |
| Journal Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume: | 25 |
| Issue: | 11 |
| ISSN: | 0362-4803 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1988-11-01 |
| Start Page: | 1219 |
| End Page: | 1228 |
| Language: | English |
| DOI: | 10.1002/jlcr.2580251108 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
