Inhibition of mitogenic activity of PDGF, EGF, and FGF by interferon-γ Journal Article

  


Author: Oleszak, E.
Article Title: Inhibition of mitogenic activity of PDGF, EGF, and FGF by interferon-γ
Abstract: Natural or recombinant human interferon-γ abolishes the mitogenic activity of platelet-derived growth factor, epidermal growth factor, and fibroblast growth factor on GM2767 or FS-4 human fibroblasts. Similarly murine interferon-γ abolishes the mitogenic activity of these growth factors on BALB/C-3T3 fibroblasts. Inhibition of DNA synthesis by interferon-γ was accomplished by blocking the transition of G0 G1 to S phase of the cell cycle. Addition of interferon-γ 15 h after the addition of growth factors (when the cells had already entered the S phase) had no effect on DNA synthesis. © 1988.
Keywords: epidermal growth factor; platelet derived growth factor; controlled study; human cell; alpha interferon; dna replication; dna synthesis; animal; mice; cell cycle; cell growth; cell line; mice, inbred balb c; gamma interferon; cell culture; platelet-derived growth factor; fibroblast; fibroblasts; beta interferon; fibroblast growth factor; fibroblast growth factors; interferon type ii; human; priority journal; cell strain gm2767
Journal Title: Experimental Cell Research
Volume: 179
Issue: 2
ISSN: 0014-4827
Publisher: Elsevier Inc.  
Date Published: 1988-12-01
Start Page: 575
End Page: 580
Language: English
DOI: 10.1016/0014-4827(88)90295-9
PUBMED: 3142786
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024233175&doi=10.1016%2f0014-4827%2888%2990295-9&partnerID=40&md5=142d8d985808b9322b4635d1defff168
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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