Effects of psyllium fiber and short-chain organic acids derived from fiber breakdown on colonic epithelial cells from high-risk patients Journal Article
| Authors: | Friedman, E.; Lightdale, C.; Winawer, S. |
| Article Title: | Effects of psyllium fiber and short-chain organic acids derived from fiber breakdown on colonic epithelial cells from high-risk patients |
| Abstract: | The effect of a purified fiber, psyllium and the short-chain organic acids derived from fiber breakdown, were assayed on isolated colonic epithelial cells primary-cultured from patients at high-risk of colon cancer, due to adenoma growth or family history of colon cancer. Psyllium fiber provided colonocytes some protection from deoxycholic acid-induced lysis. Propionic acid, a product of fiber breakdown, was a potent colonocyte mitogen, suggesting that fiber could indirectly protect the colon by providing colonocyte nutrients. © 1988. |
| Keywords: | adult; aged; human cell; cancer risk; risk factors; biopsy; cell culture; epithelium cell; epithelium; colon; middle age; colon mucosa; fiber; ispagula; deoxycholic acid; dietary fiber; human; male; female; priority journal; short chain fatty acid; support, non-u.s. gov't; colonocyte primary culture; short-chain organic acids; psyllium |
| Journal Title: | Cancer Letters |
| Volume: | 43 |
| Issue: | 1-2 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 1988-12-01 |
| Start Page: | 121 |
| End Page: | 124 |
| Language: | English |
| DOI: | 10.1016/0304-3835(88)90223-6 |
| PUBMED: | 2849504 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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