Glioneuronal tumor with neuropil-like islands (GTNI): A report of 8 cases with chromosome 1p/19q deletion analysis Journal Article

  


Authors: Barbashina, V.; Salazar, P.; Ladanyi, M.; Rosenblum, M. K.; Edgar, M. A.
Article Title: Glioneuronal tumor with neuropil-like islands (GTNI): A report of 8 cases with chromosome 1p/19q deletion analysis
Abstract: Glioneuronal tumor with neuropil-like islands (GTNI) is a rare neoplasm harboring circumscribed loci of neuronal differentiation and diffusely infiltrating astroglial and oligodendrocytelike components. We report 8 previously unpublished examples of GTNI, specifically studied for chromosome 1p and 19q allelic losses. All tumors showed characteristic histologic features and immunoprofile. One primary tumor displayed frankly malignant histology with frequent mitoses, microvascular proliferation, and necrosis. This tumor progressed within months of the initial resection. Three other tumors (2 low-grade and 1 showing only focal microvascular proliferation) recurred at 2 years, 3 years, and 1 year, respectively. All cases were evaluated for 1p/19q allelic losses by standard polymerase chain reaction-based loss of heterozygosity assays. No evidence of 1p/19q losses was found in 7 of 8 tumors. One tumor demonstrated small interstitial deletions at 1p36 (at D1S1612 and D1S513, but not at D1S548 or D1S1592) and a small interstitial deletion at 19q13 (at D19S219 and D19S412, but not at PLA2G4C). The lack of large, whole-arm 1p/19q losses (such as those found in oligodendroglial tumors), aberrant p53 expression, and the predominance of astroglial components may indicate a biologic relationship of the GTNI to diffuse astrocytoma. Although GTNI shares some morphologic features with recently reported cases of oligodendroglioma with neurocytic differentiation, the 2 tumors appear different at the molecular genetic level. © 2007 Lippincott Williams & Wilkins, Inc.
Keywords: immunohistochemistry; adult; controlled study; human tissue; aged; middle aged; cancer surgery; gene deletion; combined modality therapy; brain tumor; brain neoplasms; genetic analysis; polymerase chain reaction; cell proliferation; mitosis; cell structure; neoplasm recurrence, local; gene expression; tumor markers, biological; astrocyte; necrosis; protein p53; histology; heterozygosity; tumor recurrence; dna, neoplasm; malignant neoplastic disease; chromosomes, human, pair 19; oligodendroglioma; tumor growth; chromosome deletion; chromosomes, human, pair 1; nerve cell differentiation; astrocytoma; neuropil; microvascularization; chromosome 1p; synaptophysin; chromosome 19q; ganglioglioma; glioneuronal tumor with neuropil like island; 19q loh; 1p loh; glioneuronal tumor; neuropil-like islands
Journal Title: American Journal of Surgical Pathology
Volume: 31
Issue: 8
ISSN: 0147-5185
Publisher: Lippincott Williams & Wilkins  
Date Published: 2007-08-01
Start Page: 1196
End Page: 1202
Language: English
DOI: 10.1097/PAS.0b013e3180335f65
PUBMED: 17667543
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33846968877&partnerID=40&md5=7bb92136af4a9cf306f1ffdd5b64c520
Notes: --- - "Cited By (since 1996): 15" - "Export Date: 17 November 2011" - "CODEN: AJSPD" - "Source: Scopus"
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MSK Authors
  1. Mark Allen Edgar
    45 Edgar
  2. Marc Rosenblum
    424 Rosenblum
  3. Violetta Barbashina
    30 Barbashina
  4. Marc Ladanyi
    1326 Ladanyi
  5. Paulo A Salazar
    36 Salazar
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