Loss of heterozygosity at 19q13.3 is associated with locally aggressive neuroblastoma Journal Article
| Authors: | Mora, J.; Cheung, N. K. V.; Chen, L.; Qin, J.; Gerald, W. |
| Article Title: | Loss of heterozygosity at 19q13.3 is associated with locally aggressive neuroblastoma |
| Abstract: | A genome-wide allelic analysis of neuroblastoma (NB) revealed a previously undescribed increased incidence of loss of heterozygosity (LOH) on chromosome arm 19q13 primarily affecting stages 3 and 4N disease. Further allelic analysis of chromosome 19q13 in a cohort of 116 NB patients using 17 polymorphic microsatellite markers identified the shortest common region of loss between D19S606 and D19S112 at 19q13.3. In some cases, clonal LOH at 19q13 was acquired during the course of disease, and deleted clones remained after cytotoxic therapy. In multivariant analysis, 19q13 LOH was associated with overall survival in localregional International Neuroblastoma Staging System stages 1, 2, and 3 patients and was specifically present in tumors at the site of recurrence. |
| Keywords: | cancer survival; controlled study; human tissue; survival rate; major clinical study; cancer recurrence; recurrence risk; neoplasm recurrence, local; neuroblastoma; neoplasm metastasis; chromosomes, human, pair 19; multivariate analysis; heterozygosity loss; loss of heterozygosity; genetic markers; chromosome map; chromosome 19q; humans; prognosis; human; priority journal; article |
| Journal Title: | Clinical Cancer Research |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2001-05-01 |
| Start Page: | 1358 |
| End Page: | 1361 |
| Language: | English |
| PUBMED: | 11350906 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
