The geriatric syndrome of sarcopenia impacts allogeneic hematopoietic cell transplantation outcomes in older lymphoma patients Journal Article
| Authors: | Lin, R. J.; Michaud, L.; Lobaugh, S. M.; Nakajima, R.; Mauguen, A.; Elko, T. A.; Ruiz, J. D.; Maloy, M. A.; Sauter, C. S.; Dahi, P. B.; Perales, M. A.; Shah, G. L.; Castillo Flores, N.; Sanchez-Escamilla, M.; Tomas, A. A.; San Segundo, L. Y.; Cho, C.; Politikos, I.; Kim, S. J.; Korc-Grodzicki, B.; Devlin, S. M.; Scordo, M.; Schöder, H.; Giralt, S. A.; Hamlin, P. A. |
| Article Title: | The geriatric syndrome of sarcopenia impacts allogeneic hematopoietic cell transplantation outcomes in older lymphoma patients |
| Abstract: | Older patients with advanced hematologic malignancies are increasingly considered for allogeneic hematopoietic cell transplantation (allo-HCT) yet their survival outcomes remain suboptimal. We and others have previously shown that pre-HCT multi-morbidity and functional limitation and post-HCT geriatric syndromes significantly impact outcomes. Sarcopenia, an accelerated loss of muscle mass and function, has been increasingly recognized in older cancer patients. We identified 146 lymphoma patients 50 years or older who were allografted from 2008 to 2018 at our institution and found that before allo-HCT, 80 (55%) patients were sarcopenic. Pre-HCT sarcopenia was significantly associated with overall survival, progression-free survival, and nonrelapse mortality independent of multi-morbidity and functional limitation. In 6-month landmark analysis, post-HCT sarcopenia remained significantly associated with survival. Our findings illustrate the high prevalence and profound impact of sarcopenia on survival. While requiring prospective confirmation, preemptive, longitudinal, and multidisciplinary interventions for sarcopenia are warranted to improve HCT outcomes for older patients. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; controlled study; aged; major clinical study; overall survival; cancer patient; follow up; progression free survival; prevalence; lymphoma; allogeneic hematopoietic stem cell transplantation; body composition; geriatric assessment; muscle function; allogeneic hematopoietic cell transplantation; geriatric disorder; muscle mass; human; male; female; priority journal; article; sarcopenia; multiple chronic conditions |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 61 |
| Issue: | 8 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2020-08-01 |
| Start Page: | 1833 |
| End Page: | 1841 |
| Language: | English |
| DOI: | 10.1080/10428194.2020.1742909 |
| PUBMED: | 32228298 |
| PROVIDER: | scopus |
| PMCID: | PMC7429343 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 September 2020 -- Source: Scopus |
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