Toxic adenoma Book Section
| Authors: | Lithgow, K.; Ghaznavi, S. A.; Stephenson, A.; Mahajan, A.; Paschke, R. |
| Article/Chapter Title: | Toxic adenoma |
| Abstract: | A solitary toxic adenoma is a benign thyroid tumor with autonomous thyroid hormone production. It is a common cause of hyperthyroidism in adults, with increased prevalence seen in regions with iodine deficiency. Most solitary toxic adenomas are caused by somatic mutations that activate the thyroid-stimulating hormone (TSH) receptor. Patients with solitary toxic adenoma may present with subclinical or overt hyperthyroidism. Hyperthyroidism due to solitary toxic adenoma requires definitive treatment. Surgery and 131Iodine ablation represent the mainstays of definitive treatment. © 2019 Elsevier Inc. |
| Keywords: | genetics; mutation; adenoma; cyclic amp; hyperthyroidism; thyroid nodule; thyroid hormone; thyrotropin; iodine; receptors; thyrotoxicosis |
| Book Title: | Encyclopedia of Endocrine Diseases. 2nd ed |
| Volume: | 4 |
| ISBN: | 9780128122006 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Amsterdam, The Netherlands |
| Date Published: | 2019-01-01 |
| Start Page: | 723 |
| End Page: | 729 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-801238-3.96037-9 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter -- Source: Scopus |
