Candidate mechanisms for chemotherapy-induced cognitive changes Journal Article
| Authors: | Ahles, T. A.; Saykin, A. J. |
| Article Title: | Candidate mechanisms for chemotherapy-induced cognitive changes |
| Abstract: | The mechanism(s) for chemotherapy-induced cognitive changes are largely unknown; however, several candidate mechanisms have been identified. We suggest that shared genetic risk factors for the development of cancer and cognitive problems, including low-efficiency efflux pumps, deficits in DNA-repair mechanisms and/or a deregulated immune response, coupled with the effect of chemotherapy on these systems, might contribute to cognitive decline in patients after chemotherapy. Furthermore, the genetically modulated reduction of capacity for neural repair and neurotransmitter activity, as well as reduced antioxidant capacity associated with treatment-induced reduction in oestrogen and testosterone levels, might interact with these mechanisms and/or have independent effects on cognitive function. © 2007 Nature Publishing Group. |
| Keywords: | cancer chemotherapy; review; antineoplastic agents; neoplasms; animals; dna repair; genetic predisposition to disease; estrogen; risk factors; risk factor; brain; cognition; gene control; antioxidant activity; genetic risk; cognition disorders; nerve regeneration; progesterone; neurotransmission |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 7 |
| Issue: | 3 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-03-01 |
| Start Page: | 192 |
| End Page: | 201 |
| Language: | English |
| DOI: | 10.1038/nrc2073 |
| PUBMED: | 17318212 |
| PROVIDER: | scopus |
| PMCID: | PMC3329763 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 101" - "Export Date: 17 November 2011" - "CODEN: NRCAC" - "Source: Scopus" |
