Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumors Journal Article
| Authors: | Cavallo, F.; Feldman, D. R.; Barchi, M. |
| Article Title: | Revisiting DNA damage repair, p53-mediated apoptosis and cisplatin sensitivity in germ cell tumors |
| Abstract: | Testicular germ cell tumors (TGCTs), ie, seminomas and nonseminomas, account for 1% to 3% of all neoplasms in men. They are the most common cancer in young white males and are unique in their responsiveness to cisplatin-based chemotherapy. For this reason, TGCTs are considered a model for curative disease. However, up to now, the molecular mechanisms behind this exceptional responsiveness to DNA-damaging agents have remained unclear. A hypersensi-tive apoptotic response, as well as a reduction in the proficiency to repair cisplatin-induced DNA damage might account for this behavior. In this review, building on recent findings of p53-induced apoptosis and DNA-repair mechanisms in TGCTs, we will discuss the molecular bases that drive tumor sensitivity to cisplatin, emphasizing the new therapeutic approaches proposed to eventu-ally constrain tumor recurrence, and target TGCTs which are unresponsive to standard therapies. © 2013 UBC Press. |
| Keywords: | p53; mdm2; ercc1; homologous recombination (hr); nutlin-3; xpf |
| Journal Title: | International Journal of Developmental Biology |
| Volume: | 57 |
| Issue: | 2-4 |
| ISSN: | 0214-6282 |
| Publisher: | Universidad del Pais Vasco |
| Date Published: | 2013-01-01 |
| Start Page: | 273 |
| End Page: | 280 |
| Language: | English |
| DOI: | 10.1387/ijdb.130135mb |
| PROVIDER: | scopus |
| PUBMED: | 23784838 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2013" - "CODEN: IJDBE" - "Source: Scopus" |
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