Patient preferences for first-line treatment of classical Hodgkin lymphoma: A US survey and discrete choice experiment Journal Article
| Authors: | Khan, N.; Feliciano, J.; Müller, K.; He, M.; Tao, R.; Korol, E.; Dalal, M.; Rebeira, M.; Matasar, M. |
| Article Title: | Patient preferences for first-line treatment of classical Hodgkin lymphoma: A US survey and discrete choice experiment |
| Abstract: | A cross-sectional online survey, including a discrete choice experiment (DCE), was used to investigate first-line treatment preferences in patients with classical Hodgkin lymphoma (cHL) in the United States; 141 patients (median age 35.0 years) participated. In the DCE, risk of progression at 2 years (progression free survival) had the highest relative importance to patients (31.3%) when considering first-line treatments, followed by 2-year overall survival (OS; 26.9%), on-treatment pulmonary toxicity (23.3%), and on-treatment peripheral neuropathy (18.5%). Marginal rate of substitution analyses demonstrated that a 0.44% and 0.09% increase in 2-year OS was required for patients to accept a 1% increase in the risk of disease progression at 2 years and peripheral neuropathy, respectively. A 2.6% increase in 2-year OS was needed to accept a 7% rather than a 2% risk of pulmonary toxicity. In summary, patients with cHL rated survival attributes as more important than drug-related toxicity when considering first-line treatments. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; treatment response; aged; major clinical study; overall survival; prednisone; doxorubicin; cancer combination chemotherapy; united states; cancer patient; dacarbazine; lung toxicity; etoposide; peripheral neuropathy; cyclophosphamide; vincristine; procarbazine; vinblastine; cancer regression; bleomycin; cross-sectional study; disease exacerbation; relative; classical hodgkin lymphoma; patient preference; online system; health care survey; hodgkin; first-line treatment; human; male; female; priority journal; article; discrete choice experiment |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 61 |
| Issue: | 11 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2020-01-01 |
| Start Page: | 2630 |
| End Page: | 2637 |
| Language: | English |
| DOI: | 10.1080/10428194.2020.1783443 |
| PUBMED: | 32684056 |
| PROVIDER: | scopus |
| PMCID: | PMC9175565 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |
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