Overall survival and response to systemic therapy in metastatic extrauterine leiomyosarcoma Journal Article

Authors: Shoushtari, A. N.; Landa, J.; Kuk, D.; Sanchez, A.; Lala, B.; Schmidt, N.; Okoli, C.; Chi, P.; Dickson, M. A.; Gounder, M. M.; Keohan, M. L.; Crago, A. M.; Tap, W. D.; D'Angelo, S. P.
Article Title: Overall survival and response to systemic therapy in metastatic extrauterine leiomyosarcoma
Abstract: Background. Leiomyosarcomas (LMS) represent a heterogeneous subset of soft tissue sarcomas. Factors influencing prognosis for patients with metastatic extrauterine LMS (euLMS) are not well described. Limited data are available regarding responses to systemic therapy. Methods. We collected clinical and pathologic information for all patients with metastatic euLMS seen at Memorial Sloan Kettering Cancer Center between 1989 and 2012. Objective responses to first-line therapy were analyzed for a subset of patients with available baseline and on-treatment imaging using RECIST 1.1. Results. 215 patients with metastatic euLMS had a median overall survival (OS) of 2.6 years from the time of metastasis. Older age, male sex, and ≥3 initial sites of metastasis were associated with worse OS on multivariate analysis. Objective response rate (ORR) in N = 113 was 19% overall and 25%, 26%, and 25% for gemcitabine, gemcitabine plus docetaxel, and anthracycline-alkylator combinations. Patients whose tumors objectively responded to first-line therapy had a lower risk of death versus those who did not (Hazard Ratio 0.46; 95% CI: 0.26-0.79, p = 0.005). Conclusions. Anthracycline- and gemcitabine-based regimens have similar activity in this cohort of euLMS. Prognostic factors for OS include older age, male sex, and ≥3 initial sites. © 2016 A. N. Shoushtari et al.
Journal Title: Sarcoma
Volume: 2016
ISSN: 1357-714X
Publisher: Hindawi Publishing Corporation  
Date Published: 2016-01-01
Start Page: 3547497
Language: English
DOI: 10.1155/2016/3547497
PROVIDER: scopus
PMCID: PMC4903146
PUBMED: 27313489
Notes: Article -- Export Date: 1 July 2016 -- Source: Scopus
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MSK Authors
  1. Ping Chi
    47 Chi
  2. Jonathan Landa
    21 Landa
  3. Mary Louise Keohan
    66 Keohan
  4. Mrinal M Gounder
    74 Gounder
  5. Aimee Marie Crago
    57 Crago
  6. Mark Andrew Dickson
    79 Dickson
  7. Deborah Kuk
    81 Kuk
  8. William Douglas Tap
    129 Tap
  9. Brittany Michele Narayan Lala
    2 Lala
  10. Chika Ljeonna Okoli
    1 Okoli