Hematopoietic cell transplantation, version 2.2020 Journal Article


Authors: Saad, A.; de Lima, M.; Anand, S.; Bhatt, V. R.; Bookout, R.; Chen, G.; Couriel, D.; Di Stasi, A.; El-Jawahri, A.; Giralt, S.; Gutman, J.; Ho, V.; Horwitz, M.; Hsu, J.; Juckett, M.; Kharfan-Dabaja, M. A.; Loren, A.; Meade, J.; Mielcarek, M.; Moreira, J.; Nakamura, R.; Nieto, Y.; Roddy, J.; Satyanarayana, G.; Schroeder, M.; Tan, C. R.; Tzachanis, D.; Burn, J.; Pluchino, L.
Article Title: Hematopoietic cell transplantation, version 2.2020
Abstract: Hematopoietic cell transplantation (HCT) involves the infusion of hematopoietic progenitor cells into patients with hematologic disorders with the goal of re-establishing normal hematopoietic and immune function. HCT is classified as autologous or allogeneic based on the origin of hematopoietic cells. Autologous HCT uses the patient's own cells while allogeneic HCT uses hematopoietic cells from a human leukocyte antigen-compatible donor. Allogeneic HCT is a potentially curative treatment option for patients with certain types of hematologic malignancies, and autologous HCT is primarily used to support patients undergoing high-dose chemotherapy. Advances in HCT methods and supportive care in recent decades have led to improved survival after HCT; however, disease relapse and posttransplant complications still commonly occur in both autologous and allogeneic HCT recipients. Allogeneic HCT recipients may also develop acute and/or chronic graft-versus-host disease (GVHD), which results in immune-mediated cellular injury of several organs. The NCCN Guidelines for Hematopoietic Cell Transplantation focus on recommendations for pretransplant recipient evaluation and the management of GVHD in adult patients with malignant disease. © 2020 by the National Comprehensive Cancer Network.
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 18
Issue: 5
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2020-05-01
Start Page: 599
End Page: 634
Language: English
DOI: 10.6004/jnccn.2020.0021
PUBMED: 32519831
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 July 2020 -- Source: Scopus
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  1. Sergio Andres Giralt
    620 Giralt