Emergency management of immune-related toxicity Review
| Authors: | Cooksley, T.; Stutman, R.; Klotz, A. |
| Review Title: | Emergency management of immune-related toxicity |
| Abstract: | PURPOSE OF REVIEW: Emergency presentations in patients treated with immune checkpoint inhibitors (ICIs) are a clinical challenge. Clinicians need to be vigilant in diagnosing and treating immune-mediated toxicities. In this review, we consider the approach to managing an acutely unwell patient being treated with ICIs presenting as an emergency. RECENT FINDINGS: A minority of acutely unwell patients treated with ICIs will have an immune-mediated toxicity. Early recognition and intervention in those with immune-mediated toxicity can reduce the duration and severity of the complications. The use of early immunosuppressive agents along corticosteroid therapy may improve outcomes in patients with life-threatening immune-mediated toxicity. SUMMARY: Individualized management of immune-mediated toxicities is a key challenge for emergency oncology services; this has become part of routine cancer care. |
| Journal Title: | Current Opinion in Oncology |
| Volume: | 32 |
| Issue: | 4 |
| ISSN: | 1040-8746 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2020-07-01 |
| Start Page: | 274 |
| End Page: | 281 |
| Language: | English |
| DOI: | 10.1097/cco.0000000000000635 |
| PUBMED: | 32541313 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 July 2020 -- Source: Scopus |
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