Isolated abducens nerve palsy following pembrolizumab Journal Article

   


Authors: Jaben, K. A.; Francis, J. H.; Shoushtari, A. N.; Abramson, D. H.
Article Title: Isolated abducens nerve palsy following pembrolizumab
Abstract: Pembrolizumab is a checkpoint inhibitor targeting the programmed cell death 1 receptor of lymphocytes and is used in the treatment of solid tumours including melanoma. The authors report a 64-year-old man treated with pembrolizumab for stage IV cutaneous melanoma (primary cutaneous melanoma of the right lower back) with liver metastases. The patient developed a horizontal binocular diplopia due to an isolated unilateral cranial nerve VI palsy. Following 1 week of high dose oral steroid therapy and cessation of the drug, the patient’s nerve palsy and associated diplopic symptoms improved dramatically, and after 6 weeks of oral steroid taper and drug cessation, the palsy resolved completely. Few reports of checkpoint inhibitor autoimmune-induced isolated cranial nerve palsies have been described, and this is the first report of drug-induced isolated cranial nerve VI palsy. © 2019, © 2019 Taylor & Francis Group, LLC.
Keywords: adult; clinical article; middle aged; prednisone; fatigue; case report; drug dose reduction; drug withdrawal; cancer staging; drug megadose; ipilimumab; arthralgia; liver metastasis; hypothyroidism; levothyroxine; diplopia; cranial nerve paralysis; cutaneous melanoma; steroid therapy; vitiligo; immune checkpoint inhibitor; nivolumab; human; male; article; pembrolizumab; neurological toxicity; abducens nerve paralysis; drug-induced cranial nerve palsy; extraocular muscles; convergent strabismus; slit lamp microscopy
Journal Title: Neuro-Ophthalmology
Volume: 44
Issue: 3
ISSN: 0165-8107
Publisher: Taylor & Francis Group  
Date Published: 2020-06-01
Start Page: 182
End Page: 185
Language: English
DOI: 10.1080/01658107.2019.1566385
PROVIDER: scopus
PMCID: PMC7202430
PUBMED: 32395170
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060182154&doi=10.1080%2f01658107.2019.1566385&partnerID=40&md5=dcb24cb0bacf92152461ce1cbf08e272
Notes: Article -- Export Date: 1 June 2020 -- Source: Scopus
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MSK Authors
  1. Jasmine Helen Francis
    256 Francis
  2. David H Abramson
    389 Abramson
  3. Alexander Noor Shoushtari
    244 Shoushtari
  4. Korey A. Jaben
    7 Jaben
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