Combining immunotherapy with radiation therapy in non-small cell lung cancer Review

  


Authors: Fitzgerald, K.; Simone, C. B. 2nd
Review Title: Combining immunotherapy with radiation therapy in non-small cell lung cancer
Abstract: Immune checkpoint inhibitors have recently been demonstrated to improve survival in metastatic and locally advanced non-small cell lung cancer (NSCLC). Radiation therapy has a well-established role in the treatment of NSCLC and has more recently been shown to be immunostimulatory, with the potential to enhance the efficacy of immunotherapy. This comprehensive review details the current roles of radiation therapy and immune checkpoint inhibitors in NSCLC, discusses the intersection of these two modalities and their potential to have combined synergistic responses, and highlights existing preclinical and clinical data and ongoing clinical trials of combined immunotherapy and radiotherapy across all NSCLC stages. Copyright © 2020 Elsevier Inc. All rights reserved.
Keywords: systemic therapy; lung cancer; immunotherapy; radiation therapy; immune checkpoint inhibitors
Journal Title: Thoracic Surgery Clinics
Volume: 30
Issue: 2
ISSN: 1547-4127
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2020-04-01
Start Page: 221
End Page: 239
Language: English
DOI: 10.1016/j.thorsurg.2020.01.002
PUBMED: 32327181
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084030451&doi=10.1016%2fj.thorsurg.2020.01.002&partnerID=40&md5=c97933369ce16f7390c62e213cd83a77
Notes: Review -- Export Date: 1 June 2020 -- Source: Scopus
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MSK Authors
  1. Kelly Jean Fitzgerald
    11 Fitzgerald
  2. Charles Brian Simone
    190 Simone
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