SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes Journal Article


Authors: Sungnak, W.; Huang, N.; Bécavin, C.; Berg, M.; Queen, R.; Litvinukova, M.; Talavera-López, C.; Maatz, H.; Reichart, D.; Sampaziotis, F.; Worlock, K. B.; Yoshida, M.; Barnes, J. L.; HCA Lung Biological Network
Contributor: Pe'er, D.
Article Title: SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
Abstract: We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
Keywords: human tissue; unclassified drug; human cell; comparative study; gene expression; protein; messenger rna; epithelium cell; innate immunity; protein s 100; fetus; cathepsin b; proteinase; immune response gene; prostate stem cell antigen; marker gene; virus transmission; skeletal muscle; vitronectin; virus entry; cathepsin l; gene expression level; virus enzyme; muscle tissue; cornea epithelium; human; priority journal; article; prostate tissue; pancreas tissue; viral tropism; kidney tissue; liver tissue; spleen tissue; testis tissue; colon tissue; single cell rna seq; severe acute respiratory syndrome coronavirus 2; coronavirus disease 2019; angiotensin converting enzyme 2; atp10b protein; c15orf48 protein; cdc42ep5 protein; crym protein; cyp2f1 protein; duoxa2 protein; fam3d protein; fcgbp protein; ido1 protein; lypd2 protein; mx1 protein; oas1 protein; prkar2b protein; rarres1 protein; slc5a8 protein; spdef protein; st3gal4 enzyme; st6gal1 enzyme; tmprss2 protein; ube2l6 protein; cornea tissue; esophagus tissue; fetus tissue; heart tissue; ileum tissue; nose epithelium; retina tissue
Journal Title: Nature Medicine
Volume: 26
Issue: 5
ISSN: 1078-8956
Publisher: Nature Publishing Group  
Date Published: 2020-05-01
Start Page: 681
End Page: 687
Language: English
DOI: 10.1038/s41591-020-0868-6
PUBMED: 32327758
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 June 2020 -- Source: Scopus
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  1. Dana Pe'er
    62 Pe'er