Post-translational modifications of Runx1 regulate its activity in the cell Journal Article
| Authors: | Wang, L.; Huang, G.; Zhao, X.; Hatlen, M. A.; Vu, L.; Liu, F.; Nimer, S. D. |
| Article Title: | Post-translational modifications of Runx1 regulate its activity in the cell |
| Abstract: | In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | protein phosphorylation; leukemia; unclassified drug; acute granulocytic leukemia; methylation; histone deacetylase inhibitor; review; nonhuman; drug targeting; protein function; animals; cell cycle progression; dendritic cell; protein protein interaction; cell renewal; cell differentiation; enzyme activity; protein serine threonine kinase; dna methylation; methyltransferase; methyltransferases; dna; protein processing; transcription regulation; protein processing, post-translational; hybrid protein; drug mechanism; transcription; hematopoietic cell; vorinostat; tanespimycin; heat shock protein 90; histone deacetylases; lysine; acyltransferase; acetyltransferases; arginine; valproic acid; histone deacetylase; core binding factor alpha 2 subunit; acetylation; depsipeptide; protein eto; transcription factor runx1 |
| Journal Title: | Blood Cells, Molecules, and Diseases |
| Volume: | 43 |
| Issue: | 1 |
| ISSN: | 1079-9796 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 30 |
| End Page: | 34 |
| Language: | English |
| DOI: | 10.1016/j.bcmd.2009.03.005 |
| PUBMED: | 19386523 |
| PROVIDER: | scopus |
| PMCID: | PMC2743917 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: BCMDF" - "Source: Scopus" |
