Post-translational modifications of Runx1 regulate its activity in the cell Journal Article


Authors: Wang, L.; Huang, G.; Zhao, X.; Hatlen, M. A.; Vu, L.; Liu, F.; Nimer, S. D.
Article Title: Post-translational modifications of Runx1 regulate its activity in the cell
Abstract: In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy. © 2009 Elsevier Inc. All rights reserved.
Keywords: protein phosphorylation; leukemia; unclassified drug; acute granulocytic leukemia; methylation; histone deacetylase inhibitor; review; nonhuman; drug targeting; protein function; animals; cell cycle progression; dendritic cell; protein protein interaction; cell renewal; cell differentiation; enzyme activity; protein serine threonine kinase; dna methylation; methyltransferase; methyltransferases; dna; protein processing; transcription regulation; protein processing, post-translational; hybrid protein; drug mechanism; transcription; hematopoietic cell; vorinostat; tanespimycin; heat shock protein 90; histone deacetylases; lysine; acyltransferase; acetyltransferases; arginine; valproic acid; histone deacetylase; core binding factor alpha 2 subunit; acetylation; depsipeptide; protein eto; transcription factor runx1
Journal Title: Blood Cells, Molecules, and Diseases
Volume: 43
Issue: 1
ISSN: 1079-9796
Publisher: Elsevier Inc.  
Date Published: 2009-01-01
Start Page: 30
End Page: 34
Language: English
DOI: 10.1016/j.bcmd.2009.03.005
PUBMED: 19386523
PROVIDER: scopus
PMCID: PMC2743917
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: BCMDF" - "Source: Scopus"
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Citation Impact
MSK Authors
  1. Fang Liu
    12 Liu
  2. Gang Huang
    12 Huang
  3. Feng Liu
    2 Liu
  4. Stephen D Nimer
    347 Nimer
  5. Xinyang Zhao
    29 Zhao
  6. Fan Ying Liu
    22 Liu
  7. Fenghong Liu
    3 Liu
  8. Lan Wang
    14 Wang
  9. Fan Rong Liu
    16 Liu
  10. Ly P Vu
    31 Vu
  11. Megan A Hatlen
    14 Hatlen