Histopathologic features of lymphedema: A molecular review Review
| Authors: | Li, C. Y.; Kataru, R. P.; Mehrara, B. J. |
| Review Title: | Histopathologic features of lymphedema: A molecular review |
| Abstract: | An estimated 5 million people in the United States are affected by secondary lymphedema, with most cases attributed to malignancies or malignancy-related treatments. The pathogenesis of secondary lymphedema has historically been attributed to lymphatic injury or dysfunction; however, recent studies illustrate the complexity of lymphedema as a disease process in which many of its clinical features such as inflammation, fibrosis, adipogenesis, and recurrent infections contribute to on-going lymphatic dysfunction in a vicious cycle. Investigations into the molecular underpinning of these features further our understanding of the pathophysiology of this disease and suggests new therapeutics. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
| Keywords: | inflammation; lymphedema; fibrosis; immunity; adipogenesis; inflammatory skin conditions; recurrent infections |
| Journal Title: | International Journal of Molecular Sciences |
| Volume: | 21 |
| Issue: | 7 |
| ISSN: | 1422-0067 |
| Publisher: | MDPI |
| Date Published: | 2020-04-01 |
| Start Page: | 2546 |
| Language: | English |
| DOI: | 10.3390/ijms21072546 |
| PUBMED: | 32268536 |
| PROVIDER: | scopus |
| PMCID: | PMC7177532 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 May 2020 -- Source: Scopus |
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