Stimulation of human neuronectin secretion by brain-derived growth factors Journal Article

  


Authors: Rettig, W. J.; Triche, T. J.; Garin-Chesa, P.
Article Title: Stimulation of human neuronectin secretion by brain-derived growth factors
Abstract: Neuronectin (NEC1) is a human extracellular matrix protein found throughout the white matter of rostral brain segments but not in most areas of the mesencephalon, in the pons, cerebellum, medulla, spinal cord, and peripheral nerves. This distribution may result from NEC1 expression by a unique subset of neural cells in the rostral brain or from expression by a more widely distributed cell type, conditional on induction by region-specific extrinsic factors. In this study, we show that two brain-derived polypeptides, acidic and basic fibroblast growth factor (FGF), induce NEC1 secretion in cultured neural cells. Induction is detected within five hours after addition of FGF, is reversible, and is blocked by inhibitors of RNA and protein synthesis. Other growth and differentiation factors do not induce NEC1, except for 12-O-tetradecanoyl phorbol-13-acetate, which acts through a different signalling pathway. Acidic and basic FGF may be members of a group of extrinsic factors that determine region-specific NEC1 expression in neural tissues. © 1989.
Keywords: human cell; gene expression; cell line; nerve tissue proteins; tumor cells, cultured; central nervous system; time factors; extracellular matrix; cell culture; brain; neuroblastoma; sarcoma, ewing's; astrocytoma; fibroblast growth factor; fibroblast growth factors; phorbol ester; neuroectodermal tumors, primitive, peripheral; tetradecanoylphorbol acetate; human; priority journal; neuronectin
Journal Title: Brain Research
Volume: 487
Issue: 1
ISSN: 0006-8993
Publisher: Elsevier Science, Inc.  
Date Published: 1989-05-15
Start Page: 171
End Page: 177
Language: English
DOI: 10.1016/0006-8993(89)90954-2
PUBMED: 2752284
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024405154&doi=10.1016%2f0006-8993%2889%2990954-2&partnerID=40&md5=59024bf3bb4ba154fdbeb37785eaf4ee
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Pilar Garin-Chesa
    73 Garin-Chesa
  2. Wolfgang J. Rettig
    85 Rettig
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