Definition of an extracellular matrix protein in rostral portions of the human central nervous system Journal Article

  


Authors: Rettig, W. J.; Garin Chesa, P.; Beresford, H. R.; Melamed, M. R.; Old, L. J.
Article Title: Definition of an extracellular matrix protein in rostral portions of the human central nervous system
Abstract: We have identified and characterized an extracellular matrix (ECM) glycoprotein of cultured astrocytomes, NEC1, that is expressed in normal human brain parenchyma. Detailed immunohistochemical analysis reveals a region-specific NEC1 pattern along the rostrocaudal axis of the central nervous system (CNS), with strong expression throughout the white matter of telencephalon and diencephalon, scant expression in some areas of mesencephalon, and no expression in pons, cerebellum, medulla, spinal cord, and peripheral nervous system. NEC1 is not co-distributed with any known neural cell type, suggesting that expression of specific ECM proteins in the CNS is segmentally controlled. © 1988.
Keywords: immunohistochemistry; human cell; brain neoplasms; tumor cells, cultured; central nervous system; monoclonal antibody; extracellular matrix; antibodies, monoclonal; cell culture; brain; histochemistry; neuroglia; antibody specificity; autopsy; astrocytoma; glycoprotein; brain region; fibronectins; human; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; brain segment
Journal Title: Brain Research
Volume: 438
Issue: 1-2
ISSN: 0006-8993
Publisher: Elsevier Science, Inc.  
Date Published: 1988-01-12
Start Page: 315
End Page: 322
Language: English
DOI: 10.1016/0006-8993(88)91355-8
PUBMED: 3345437
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023871111&doi=10.1016%2f0006-8993%2888%2991355-8&partnerID=40&md5=2b46fefd2231fa83de6178a8d67b1baf
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Lloyd J Old
    593 Old
  2. Pilar Garin-Chesa
    73 Garin-Chesa
  3. Wolfgang J. Rettig
    85 Rettig
  4. Myron Melamed
    148 Melamed
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