Synthetic studies toward (+)-cortistatin A Journal Article

Authors: Wang, Z.; Dai, M.; Park, P. K.; Danishefsky, S. J.
Article Title: Synthetic studies toward (+)-cortistatin A
Abstract: We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6π-electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the total synthesis we sought was not accomplished, the work sets the stage for several approaches to the preparation of novel analogs via diverted total synthesis. © 2011 Elsevier B.V. All rights reserved.
Keywords: unclassified drug; angiogenesis inhibitor; drug structure; drug synthesis; cortistatin; cyclization; technique; reaction analysis; chemical reaction; total synthesis; stereochemistry; chemical modification; cycloaddition; dearomatization; cortistatin a; nitrone-aryne cycloaddition; cortistatin b; cortistatin c; cortistatin d; cortistatin e; cortistatin f; cortistatin g; cortistatin h; cortistatin j; cortistatin k; cortistatin l; electrocyclization; 6?-electrocyclization
Journal Title: Tetrahedron
Volume: 67
Issue: 52
ISSN: 0040-4020
Publisher: Elsevier Inc.  
Date Published: 2011-01-01
Start Page: 10249
End Page: 10260
Language: English
DOI: 10.1016/j.tet.2011.10.026
PROVIDER: scopus
PMCID: PMC3413295
PUBMED: 22879684
Notes: --- - "Export Date: 3 January 2012" - "CODEN: TETRA" - "Source: Scopus"
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MSK Authors
  1. Peter Kinam Park
    9 Park