Prognostic factors for relapse after complete response in patients with metastatic germ cell tumors Journal Article

  


Authors: Geller, N. L.; Bosl, G. J.; Chan, E. Y. W.
Article Title: Prognostic factors for relapse after complete response in patients with metastatic germ cell tumors
Abstract: Among 216 patients with metastatic germ cell tumors who achieved a complete response (CR) to cisplatin‐based chemotherapy (CT), 38 have experienced a relapse. Prognostic factors for time to relapse from time of response were considered using the Cox proportional hazards model. Compared with patients who responded to CT and did not require surgery and patients whose surgery showed only either necrotic debris or mature teratoma, those who required surgery for residual tumor after CT were at much higher risk for relapse, although their residual tumor was totally resected. Of the 19 patients who required this surgery, eight have experienced a relapse. Other prognostic factors for relapse included lactate dehydrogenase (LDH) and human chorionic gonadatropin (hCG) at the time of initial CT. Although those who require surgery for residual tumor after CT receive additional CT, there is still a high risk of relapse. Copyright © 1989 American Cancer Society
Keywords: adult; major clinical study; cancer recurrence; cisplatin; metastasis; neoplasm recurrence, local; tomography, x-ray computed; vinblastine; testicular neoplasms; dactinomycin; bleomycin; teratoma; lactate dehydrogenase; germ cell tumor; chorionic gonadotropin; mathematics; prognosis; human; male; priority journal; support, u.s. gov't, p.h.s.
Journal Title: Cancer
Volume: 63
Issue: 3
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1989-02-01
Start Page: 440
End Page: 445
Language: English
DOI: 10.1002/1097-0142(19890201)63:3<440::Aid-cncr2820630308>3.0.Co;2-7
PUBMED: 2912523
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024591009&doi=10.1002%2f1097-0142%2819890201%2963%3a3%3c440%3a%3aAID-CNCR2820630308%3e3.0.CO%3b2-7&partnerID=40&md5=613ea4023460bcf4e9348b4889ee64d8
Notes: Article -- Source: Scopus
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MSK Authors
  1. George Bosl
    430 Bosl
  2. Nancy L. Geller
    65 Geller
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