Effect on in vivo tumorigenicity of lengthy exposure of human colon cancer cells to the differentiation agent hexamethylene bisacetamide Journal Article
| Authors: | Schroy, P.; Winawer, S.; Friedman, E. |
| Article Title: | Effect on in vivo tumorigenicity of lengthy exposure of human colon cancer cells to the differentiation agent hexamethylene bisacetamide |
| Abstract: | The heterogeneity of tumor responses to maturation agents was studied using the multipotential, non-cloned human colon carcinoma cell line HT29. Short-term treatment (5 cell doublings) with the differentiation agent hexamethylene bisacetamide (HMBA) induced a sharp decrease in tumorigenicity in vivo and loss of a cell surface malignancy marker. However, prolonged treatment (22 cell doublings) with the agent lead to loss of the HMBA-sensitive subpopulation from the mass culture, and enrichment of a tumorigenic, HMBA-resistant subpopulation. © 1989. |
| Keywords: | human cell; mouse; animal; mice; tumor markers, biological; animal experiment; colonic neoplasms; drug resistance; tumor cells, cultured; antibodies, monoclonal; antigens, neoplasm; cell culture; mice, nude; carcinogenicity; cell subpopulation; tumor cell; neoplasm transplantation; colon carcinoma; cytochemistry; tumorigenicity; hexamethylenebisacetamide; hexamethylene bisacetamide; acetamides; human; priority journal; support, u.s. gov't, p.h.s.; human colon cancer |
| Journal Title: | Cancer Letters |
| Volume: | 48 |
| Issue: | 1 |
| ISSN: | 0304-3835 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 1989-11-15 |
| Start Page: | 53 |
| End Page: | 58 |
| Language: | English |
| DOI: | 10.1016/0304-3835(89)90202-4 |
| PUBMED: | 2819696 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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