Effect on in vivo tumorigenicity of lengthy exposure of human colon cancer cells to the differentiation agent hexamethylene bisacetamide Journal Article


Authors: Schroy, P.; Winawer, S.; Friedman, E.
Article Title: Effect on in vivo tumorigenicity of lengthy exposure of human colon cancer cells to the differentiation agent hexamethylene bisacetamide
Abstract: The heterogeneity of tumor responses to maturation agents was studied using the multipotential, non-cloned human colon carcinoma cell line HT29. Short-term treatment (5 cell doublings) with the differentiation agent hexamethylene bisacetamide (HMBA) induced a sharp decrease in tumorigenicity in vivo and loss of a cell surface malignancy marker. However, prolonged treatment (22 cell doublings) with the agent lead to loss of the HMBA-sensitive subpopulation from the mass culture, and enrichment of a tumorigenic, HMBA-resistant subpopulation. © 1989.
Keywords: human cell; mouse; animal; mice; tumor markers, biological; animal experiment; colonic neoplasms; drug resistance; tumor cells, cultured; antibodies, monoclonal; antigens, neoplasm; cell culture; mice, nude; carcinogenicity; cell subpopulation; tumor cell; neoplasm transplantation; colon carcinoma; cytochemistry; tumorigenicity; hexamethylenebisacetamide; hexamethylene bisacetamide; acetamides; human; priority journal; support, u.s. gov't, p.h.s.; human colon cancer
Journal Title: Cancer Letters
Volume: 48
Issue: 1
ISSN: 0304-3835
Publisher: Elsevier Ireland Ltd.  
Date Published: 1989-11-15
Start Page: 53
End Page: 58
Language: English
DOI: 10.1016/0304-3835(89)90202-4
PUBMED: 2819696
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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  1. Sidney J Winawer
    274 Winawer
  2. Paul C. Schroy
    12 Schroy