Granulocyte colony-stimulating factor: Preclinical and clinical studies Journal Article

  


Authors: Gabrilove, J. L.; Jakubowski, A.
Article Title: Granulocyte colony-stimulating factor: Preclinical and clinical studies
Abstract: The production of neutrophil granulocytes is a complex and dynamic process during which a small number of self-renewing stem cells give rise to lineage-specific progenitors. One hematopoietic glycoprotein that appears to specifically cotnrol the survival, cycle activation, proliferation and terminal maturation of this myeloid lineage is granulocyte colony-stimulating factor (G-CSF). Some topics discussed are its molecular characterization, biochemical purification, sources, and effects of administration.
Keywords: neutropenia; review; nonhuman; neoplasms; animal; drug evaluation, preclinical; drug synthesis; leukemia cell; recombinant proteins; hematopoiesis; rodentia; bone marrow transplantation; granulocyte colony stimulating factor; granulocyte colony-stimulating factor; colony-stimulating factors; primates; drug evaluation; agranulocytosis; bone marrow diseases; human
Journal Title: Hematology/Oncology Clinics of North America
Volume: 3
Issue: 3
ISSN: 0889-8588
Publisher: Elsevier Inc.  
Date Published: 1989-09-01
Start Page: 427
End Page: 440
Language: English
PUBMED: 2483722
PROVIDER: scopus
DOI: 10.1016/S0889-8588(18)30539-2
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024406448&partnerID=40&md5=028b67fe90f1da4ae6aa79db4066935c
Notes: Review -- Source: Scopus
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MSK Authors
  1. Ann Jakubowski
    455 Jakubowski
  2. Janice Gabrilove
    122 Gabrilove
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