Role of interleukin-1 in hematopoiesis Journal Article
| Author: | Moore, M. A. S. |
| Article Title: | Role of interleukin-1 in hematopoiesis |
| Abstract: | IL-1 is considered a phylogenetically old molecule that predates the evolution of lymphocytes and immunoglobulins [35]. Its activities transcend immune function and encompass general inflammatory changes induced by pathogenic organisms. Depending upon the degree of endogenous activation of IL-1 production, its pleiotropic actions may be efficacious or deleterious. In so far as IL-1 has potential as a myelostimulatory agent in idiopathic or iatrogenic neutropenias, it has proved critical to define a dose and timing of administration designed to facilitate hematopoietic stimulation and yet avoid toxicity. Preclinical studies suggest that this is an attainable goal and clinical trials are currently underway. © 1989 Humana Press Inc. |
| Keywords: | fluorouracil; nonhuman; animal cell; mouse; animal; mice; biological model; bone marrow; animal experiment; animal model; stem cell; cytokine; cytokines; cell culture; hematopoietic stem cells; radiation-protective agents; hematopoiesis; bone marrow transplantation; monkey; granulocyte colony-stimulating factor; cytochemistry; colony-stimulating factors; in vitro; biological factors; interleukin 1; interleukin-1; tissue culture; human; lymphokine |
| Journal Title: | Immunologic Research |
| Volume: | 8 |
| Issue: | 3 |
| ISSN: | 0257-277X |
| Publisher: | Springer |
| Date Published: | 1989-09-01 |
| Start Page: | 165 |
| End Page: | 175 |
| Language: | English |
| DOI: | 10.1007/bf02918142 |
| PUBMED: | 2473152 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
