Presence of tumour necrosis factor or a related factor in human basophil/mast cells Journal Article
| Authors: | Steffen, M.; Abboud, M.; Potter, G. K.; Yung, Y. P.; Moore, M. A. S. |
| Article Title: | Presence of tumour necrosis factor or a related factor in human basophil/mast cells |
| Abstract: | The observation that mast cell products and cachectin/tumour necrosis factor (TNF) mediate similar responses suggested an investigation of cultured human basophil/mast cells for production of TNF. Using in situ hybridization and the avidin-biotin-complex (ABC) immunoperoxidase method, we have demonstrated the presence of TNF mRNA in the cytoplasm and TNF protein in the granules of individual human basophil/mast cells. The production of TNF by these cells could explain many of their reported functions. |
| Keywords: | human cell; cells, cultured; cell culture; messenger rna; cytoplasm; cytochemistry; tumor necrosis factor; mast cell; mast cells; basophil; basophils; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Immunology |
| Volume: | 66 |
| Issue: | 3 |
| ISSN: | 0019-2805 |
| Publisher: | Wiley-Blackwell Publishing Ltd |
| Date Published: | 1989-03-01 |
| Start Page: | 445 |
| End Page: | 450 |
| Language: | English |
| PUBMED: | 2703257 |
| PROVIDER: | scopus |
| PMCID: | PMC1385235 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
