Lymphatic vessel invasion is an independent prognostic factor for survival in colorectal cancer Journal Article
| Authors: | Minsky, B. D.; Mies, C.; Rich, T. A.; Recht, A. |
| Article Title: | Lymphatic vessel invasion is an independent prognostic factor for survival in colorectal cancer |
| Abstract: | To assess whether lymphatic vessel invasion (LVI) is an independent prognostic factor in colorectal cancer, we retrospectively reviewed the records of 462 patients who underwent potentially curative surgery for carcinoma of the colon and rectosigmoid/rectum (rs/rectum) at the New England Deaconess Hospital from 1965-1978. Sixty-one patients were identified as having tumors with lymphatic vessel invasion (LVI+), and they were compared with the remaining group of 401 patients who had tumors without lymphatic vessel invasion (LVI-). The incidence of lymphatic vessel invasion was significantly increased in tumors with blood vessel invasion (24% vs. 5%, p = 0.000001). Patients with LVI+ tumors also had a significantly increased incidence of positive nodes (59% vs. 25%, p = 0.0004), the average number of positive nodes (4.8 vs. 2.2, p = 0.0003), and a lower 5-year survival rate (colon: 57% vs. 84%, p = 0.0001; rs/rectum: 38% vs. 71%, p = 0.004). There was a significant (p ≤ 0.05) increase in local (16% vs. 7%), abdominal (33% vs. 9%), and distant (13% vs. 4%) failure as a component of failure in patients with LVI+ colon cancer and a significant increase in abdominal (33% vs. 11%) and distant (13% vs. 8%) failure as a component of failure in patients with LVI+ rectosigmoid/rectal cancer. Proportional hazards analysis demonstrated that lymphatic vessel invasion was an independent prognostic factor for survival. © 1989. |
| Keywords: | adult; aged; aged, 80 and over; retrospective studies; major clinical study; colorectal cancer; adenocarcinoma; adenocarcinoma, mucinous; colorectal carcinoma; colorectal neoplasms; cancer invasion; lymph vessel; lymphatic system; patterns of failure; middle age; prognosis; human; male; female; priority journal; support, non-u.s. gov't; lymphatic vessel invasion |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 17 |
| Issue: | 2 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1989-08-01 |
| Start Page: | 311 |
| End Page: | 318 |
| Language: | English |
| DOI: | 10.1016/0360-3016(89)90445-8 |
| PUBMED: | 2546907 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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