Transformation of human kidney proximal tubule cells by ras-containing retroviruses: Implications for tumor progression Journal Article

   

Authors:	Nanus, D. M.; Ebrahim, S. A. D.; Bander, N. H.; Real, F. X.; Pfeffer, L. M.; Shapiro, J. R.; Albino, A. P.
Article Title:	Transformation of human kidney proximal tubule cells by ras-containing retroviruses: Implications for tumor progression
Abstract:	Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These incloude changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells.
Keywords:	cytogenetics; immunofluorescence; kidney carcinoma; cell culture; histochemistry; tumor growth; chromosome 21; oncogene ras; kidney proximal tubule; human; priority journal
Journal Title:	Journal of Experimental Medicine
Volume:	169
Issue:	3
ISSN:	0022-1007
Publisher:	Rockefeller University Press
Date Published:	1989-03-01
Start Page:	953
End Page:	972
Language:	English
DOI:	10.1084/jem.169.3.953
PUBMED:	2494294
PROVIDER:	scopus
PMCID:	PMC2189254
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024556427&doi=10.1084%2fjem.169.3.953&partnerID=40&md5=0d8485a620e4e0fd3b88890453645fab
Notes:	Article -- Export Date: 14 April 2020 -- Source: Scopus

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