Immunophenotypic differences between normal glia, astrocytomas and malignant gliomas: Correlations with karyotype, natural history and survival Journal Article

  

Authors:	Jennings, M. T.; Ebrahim, S. A. D.; Thaler, H. T.; Jennings, V. D. L.; Asadourian, L. L. H.; Shapiro, J. R.
Article Title:	Immunophenotypic differences between normal glia, astrocytomas and malignant gliomas: Correlations with karyotype, natural history and survival
Abstract:	The karyotypic and antigenic phenotypes of early passage normal and malignant glial cultures were correlated in vitro. Astrocytomas (4) were distinguished from the normal glia (8) by a mixed near-diploid karyotype and anchorage-independent growth. Malignant gliomas (41) demonstrated cytogenetic abnormalities ranging from mixed normal G- and Q-banded and near-diploid culture, through mixed near-diploid/hyperdiploid to predominantly hyperdiploid stem-lines. This correlated with the differential expression of certain antigens and established qualitative antigenic differences from normal glia.Associations were found between histopathologic grade of glial neoplasm and the expression of antigens 5.1H11 (p = 0.0002), CNT/11 (p = 0.001), CNT/10 (p = 0.004), CAT301 (p = 0.014), M111 (p = 0.024), and L101 (p = 0.044). An ominous association was demonstrated between the duration of clinical survival and the expression of antigens 5.1H11 (p = 0.0007), CNT/10 (p = 0.027) and B2.6 (p = 0.038). Correcting for diagnosis and age, multivariate analysis demonstrated that HLA-DR (p = 0.050) and 5.1H11 (p = 0.069) were unfavorably correlated with patient survival. This suggests the application of the in vitro immunophenotype for its predictive utility, as well as a novel method of selection of tumor-associated antigens for monoclonal antibody-mediated immunotherapy. © 1989.
Keywords:	adolescent; adult; child; clinical article; survival analysis; glioma; phenotype; statistics; cytogenetics; tumor cells, cultured; history; immunology; neuroglia; karyotype; karyotyping; astrocytoma; neuroectoderm tumor; glia; malignant glioma; immunologic techniques; prognosis; human; priority journal; cytogenesis; (prognosis); neuroectodermal tumor antigen
Journal Title:	Journal of Neuroimmunology
Volume:	25
Issue:	1
ISSN:	0165-5728
Publisher:	Elsevier Inc.
Date Published:	1989-11-01
Start Page:	7
End Page:	28
Language:	English
DOI:	10.1016/0165-5728(89)90082-9
PUBMED:	2685039
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024387062&doi=10.1016%2f0165-5728%2889%2990082-9&partnerID=40&md5=cf137b76551c601496adf138896cdbd0
Notes:	Article -- Export Date: 14 April 2020 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/164492