In vitro karyotypic and immunophenotypic characterisation of primitive neuroectodermal tumours: Similarities to malignant gliomas Journal Article

  


Authors: Jennings, M. T.; Jennings, D. L.; Ebrahim, S. A. D.; Johnson, M. D.; Turc-Carel, C.; Philip, T.; Philip, I.; Lapras, C.; Shapiro, J. R.
Article Title: In vitro karyotypic and immunophenotypic characterisation of primitive neuroectodermal tumours: Similarities to malignant gliomas
Abstract: Monoclonal antibody (Mab) mediated immunotherapy of brain tumours requires the identification of tumour-restricted cell surface antigens. We have characterised four primitive neuroectodermal tumours, which included pineoblastoma, medulloblastoma and ependymoblastoma cultures, that demonstrated in vitro evidence of malignant behaviour (anchorage-independent growth and nu/nu xenograft tumour formation). The cytogenetic findings ranged from normal G-banded and Q-banded karyotypes through mixed near-diploid/hyperdiploid. These cultures resembled the cell surface immunophenotypic spectrum of malignant gliomas. They were distinguished from normal glia in vitro by the expression of restricted fetal mesenchymal, neuronal, myoblastic, melanocytic, epidermal, chondrocytic, lymphoid and epithelial antigens. Certain antigens appeared sufficiently represented among central nervous system (CNS) neoplasms to afford potential targets for Mab-mediated immunotherapy. © 1992.
Keywords: immunohistochemistry; adolescent; human cell; glioma; brain neoplasms; phenotype; tumor cells, cultured; central nervous system neoplasms; antibodies, monoclonal; infant; medulloblastoma; immunophenotyping; ependymoma; neoplasms, germ cell and embryonal; karyotype; karyotyping; cerebellar neoplasms; neuroectoderm tumor; pinealoma; human; male; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: European Journal of Cancer
Volume: 28
Issue: 4-5
ISSN: 0959-8049
Publisher: Elsevier Inc.  
Date Published: 1992-04-01
Start Page: 762
End Page: 766
Language: English
DOI: 10.1016/0959-8049(92)90111-e
PUBMED: 1326305
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026529382&doi=10.1016%2f0959-8049%2892%2990111-E&partnerID=40&md5=4dfc7dc091a367baf548f825253ea314
Notes: Article -- Export Date: 30 July 2019 -- Source: Scopus
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MSK Authors
  1. Joan Rankin Shapiro
    27 Shapiro
  2. Salah A. D. Ebrahim
    15 Ebrahim
  3. Mark Jennings
    15 Jennings
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