Near infrared photonic finger imager for prostate cancer screening Journal Article
| Authors: | Pu, Y.; Wang, W. B.; Xu, M.; Tang, G. C.; Budansky, Y.; Sharanov, M.; Achilefu, S.; Eastham, J. A.; Alfano, R. R. |
| Article Title: | Near infrared photonic finger imager for prostate cancer screening |
| Abstract: | A portable rectal near infrared (NIR) scanning polarization imaging unit with an optical fiber-based rectal probe, designated as a Photonic Finger (PF), was designed, developed, built and tested. PF was used to image and locate the three dimensional (3D) positions of abnormal prostate tissue embedded inside normal prostate tissue. An inverse image reconstruction algorithm, namely Optical Tomography using Independent Component Analysis (OPTICA) was developed to unmix the signal from targets (cancerous tissue) embedded in a turbid media (normal tissue) in the backscattering imaging geometry. The Photonic Finger combined with OPTICA was ex vivo tested to characterize different target(s) inside different tissue medium, including cancerous prostate tissue embedded inside large pieces of normal tissue. This new developed instrument, Photonic Finger, may provide an alternative imaging technique, which is accurate, of high spatial resolution and non-or-less invasive for prostate cancers screening. © Adenine Press (2011). |
| Keywords: | animals; cancer screening; algorithms; prostate cancer; prostatic neoplasms; prostate; algorithm; optical tomography; tomography, optical; three dimensional imaging; device; computer simulation; photons; mammary glands, animal; early detection of cancer; image reconstruction; chickens; independent component analysis; infrared rays; backscattering; human prostate tissue; independent component analysis (ica); optical fiber-based rectal probe; photon propagation model; photonic finger (pf); receptor-target contrast agents; scanning optical polarization imaging; three-dimensional localization; near infrared spectroscopy; scintillation probe |
| Journal Title: | Technology in Cancer Research & Treatment |
| Volume: | 10 |
| Issue: | 6 |
| ISSN: | 1533-0346 |
| Publisher: | Sage Publications, Inc. |
| Date Published: | 2011-12-01 |
| Start Page: | 507 |
| End Page: | 517 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 22066592 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 3 January 2012" - "CODEN: TCRTB" - "Source: Scopus" |
