CT-SPECT fusion to correlate radiolabled monoclonal antibody uptake with abdominal CT findings Journal Article
| Authors: | Kramer, E. L.; Noz, M. E.; Sanger, J. J.; Megibow, A. J.; Maguire, G. Q. |
| Article Title: | CT-SPECT fusion to correlate radiolabled monoclonal antibody uptake with abdominal CT findings |
| Abstract: | To enhance the information provided by computed tomography (CT) and single photo emission computed tomography (SPECT) performed with radiolabeled, anti-carcinoembryonic antigen monoclonal antibody (MoAb), the authors performed fusion of these types of images from eight subjects with suspected colorectal adenocarcinoma. Section thickness and pixel size of the two studies were matched, coordinates of corresponding points from each study were identified, and CT sections were translated, rotated, and reprojected to match the corresponding SPECT scans. The CT-SPECT fusion enabled identification of anatomic sites of tumor-specific MoAb accumulation in four cases, showed non-specific MoAb accumulation in two, and helped confirm information only suggested by the two studies separately in one. |
| Keywords: | adult; clinical article; aged; methodology; computer assisted tomography; colorectal carcinoma; radioisotope; single photon emission computer tomography; intravenous drug administration; abdominal radiography; computer analysis; immunoscintigraphy; human; male; female; priority journal; carcinoembryonic antigen monoclonal antibody |
| Journal Title: | Radiology |
| Volume: | 172 |
| Issue: | 3 |
| ISSN: | 0033-8419 |
| Publisher: | Radiological Society of North America, Inc. |
| Date Published: | 1989-09-01 |
| Start Page: | 861 |
| End Page: | 865 |
| Language: | English |
| DOI: | 10.1148/radiology.172.3.2788895 |
| PUBMED: | 2788895 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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