Synchronous follicular lymphoma, kaposi sarcoma, and Castleman's disease in a HIV-negative patient with EBV and HHV-8 coinfection Journal Article
| Authors: | Koreishi, A. F.; Saenz, A. J.; Arcila, M. E.; Hedvat, C.; Fleming, S.; Teruya-Feldstein, J. |
| Article Title: | Synchronous follicular lymphoma, kaposi sarcoma, and Castleman's disease in a HIV-negative patient with EBV and HHV-8 coinfection |
| Abstract: | The authors describe the case of a 65-year-old woman who was HIV negative and had a lymph node biopsy that showed concurrent follicular lymphoma (FL; grade 3A), Kaposi sarcoma (KS), and Castleman's disease (CD) with coinfection by human herpes virus-8 (HHV-8) and Epstein-Barr virus (EBV). The lymphoma was positive for CD20, CD10, and BCL6 and negative for BCL2. Flow cytometry showed a clonal lambda B-cell population, and polymerase chain reaction (PCR) showed a clonal immunoglobulin heavy chain gene rearrangement, confirming a neoplastic B-cell process. Focally, the FL component showed numerous EBER1-positive cells, with rare HHV-8-positive cells. The KS component showed strong HHV-8 expression with rare EBER1-positive cells. The CD component showed scattered HHV-8, viral interleukin-6, and EBER1-positive cells. The simultaneous occurrence of a FL, KS, and CD in an HIV-negative patient expands the spectrum of HHV-8-positive neoplasms and suggests the possibility of HHV-8 rendering mature B-cells hyperresponsive to antigenic stimulation, providing an expanded target for second site mutations or cytokine-driven hyperplasia, culminating in lymphoma. © SAGE Publications 2011. |
| Keywords: | immunohistochemistry; human tissue; aged; prednisone; case report; doxorubicin; drug withdrawal; rituximab; flow cytometry; polymerase chain reaction; aciclovir; cyclophosphamide; diagnostic imaging; b lymphocyte; acute kidney failure; cd20 antigen; gene rearrangement; pancreatitis; interleukin 6; nausea and vomiting; pleura effusion; protein bcl 6; large cell lymphoma; kaposi sarcoma; sarcoma, kaposi; aspiration biopsy; drug substitution; neoplasms, multiple primary; follicular lymphoma; lymphoma, follicular; lymph node biopsy; epstein barr virus; diabetes mellitus, type 2; human herpesvirus 8; herpesvirus 8, human; hepatosplenomegaly; epstein-barr virus infections; common acute lymphoblastic leukemia antigen; gastritis; castleman's disease; ebv; hhv-8; vil-6; angiofollicular lymph node hyperplasia; immunoglobulin heavy chain gene; giant lymph node hyperplasia; coinfection |
| Journal Title: | International Journal of Surgical Pathology |
| Volume: | 19 |
| Issue: | 5 |
| ISSN: | 1066-8969 |
| Publisher: | Sage Publications |
| Date Published: | 2011-10-01 |
| Start Page: | 685 |
| End Page: | 691 |
| Language: | English |
| DOI: | 10.1177/1066896909341803 |
| PROVIDER: | scopus |
| PUBMED: | 19661098 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: IJSPF" - "Source: Scopus" |
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