The cancer microbiome: Distinguishing direct and indirect effects requires a systemic view Review
| Authors: | Xavier, J. B.; Young, V. B.; Skufca, J.; Ginty, F.; Testerman, T.; Pearson, A. T.; Macklin, P.; Mitchell, A.; Shmulevich, I.; Xie, L.; Caporaso, J. G.; Crandall, K. A.; Simone, N. L.; Godoy-Vitorino, F.; Griffin, T. J.; Whiteson, K. L.; Gustafson, H. H.; Slade, D. J.; Schmidt, T. M.; Walther-Antonio, M. R. S.; Korem, T.; Webb-Robertson, B. J. M.; Styczynski, M. P.; Johnson, W. E.; Jobin, C.; Ridlon, J. M.; Koh, A. Y.; Yu, M.; Kelly, L.; Wargo, J. A. |
| Review Title: | The cancer microbiome: Distinguishing direct and indirect effects requires a systemic view |
| Abstract: | The collection of microbes that live in and on the human body – the human microbiome – can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell–cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology – a systems biology approach. © 2020 The Author(s) |
| Keywords: | cancer chemotherapy; review; cancer growth; nonhuman; cancer radiotherapy; cancer staging; antineoplastic agent; cancer immunotherapy; cancer prevention; cancer pain; diagnostic value; feedback system; intestine flora; cell interaction; cancer immunology; microbial community; host factor; human; priority journal; microbial metabolism; malignant neoplasm; tumor virus; microbial interaction |
| Journal Title: | Trends in Cancer |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Date Published: | 2020-03-01 |
| Start Page: | 192 |
| End Page: | 204 |
| Language: | English |
| DOI: | 10.1016/j.trecan.2020.01.004 |
| PUBMED: | 32101723 |
| PROVIDER: | scopus |
| PMCID: | PMC7098063 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 April 2020 -- Source: Scopus |
