The evolution of the host microbiome as an ecosystem on a leash Journal Article
| Authors: | Foster, K. R.; Schluter, J.; Coyte, K. Z.; Rakoff-Nahoum, S. |
| Article Title: | The evolution of the host microbiome as an ecosystem on a leash |
| Abstract: | The human body carries vast communities of microbes that provide many benefits. Our microbiome is complex and challenging to understand, but evolutionary theory provides a universal framework with which to analyse its biology and health impacts. Here we argue that to understand a given microbiome feature, such as colonization resistance, host nutrition or immune development, we must consider how hosts and symbionts evolve. Symbionts commonly evolve to compete within the host ecosystem, while hosts evolve to keep the ecosystem on a leash. We suggest that the health benefits of the microbiome should be understood, and studied, as an interplay between microbial competition and host control. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. |
| Journal Title: | Nature |
| Volume: | 548 |
| Issue: | 7665 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2017-08-03 |
| Start Page: | 43 |
| End Page: | 51 |
| Language: | English |
| DOI: | 10.1038/nature23292 |
| PROVIDER: | scopus |
| PUBMED: | 28770836 |
| PMCID: | PMC5749636 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 5 September 2017 -- Source: Scopus |
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