Monoclonal antibodies in multiple myeloma: Current and emerging targets and mechanisms of action Review

   


Authors: Wudhikarn, K.; Wills, B.; Lesokhin, A. M.
Review Title: Monoclonal antibodies in multiple myeloma: Current and emerging targets and mechanisms of action
Abstract: The recent development of monoclonal antibodies (mAbs) has revolutionized the treatment armamentarium for multiple myeloma. The success of daratumumab and elotuzumab in relapsed/refractory patients, has generated tremendous enthusiasm for mAbs in this disease. Combination treatment with other anti-myeloma treatment modalities and clinical evaluation in newly diagnosed patients are expected to fundamentally change the natural history of the disease. Advances in biopharmaceutical engineering together with a robust interest in novel mAb-derivatives, including antibody drug conjugates and poly-specific antibodies are the next rapidly approaching treatment frontier in multiple myeloma. In this review, we comprehensively outline the currently available evidence and the future landscape of mAbs and mAb-derivative therapies in multiple myeloma. © 2020 Elsevier Ltd
Keywords: review; monotherapy; nonhuman; cancer immunotherapy; multiple myeloma; monoclonal antibody; drug mechanism; cd19 antigen; syndecan 1; molecularly targeted therapy; bispecific antibody; human; priority journal; elotuzumab; b cell maturation antigen; daratumumab; isatuximab; antineoplastic monoclonal antibody; adp ribosyl cyclase/cyclic adp ribose hydrolase 1; antibody drug conjugate
Journal Title: Best Practice and Research: Clinical Haematology
Volume: 33
Issue: 1
ISSN: 1521-6926
Publisher: Elsevier Inc.  
Date Published: 2020-03-01
Start Page: 101143
Language: English
DOI: 10.1016/j.beha.2020.101143
PUBMED: 32139009
PROVIDER: scopus
PMCID: PMC7060936
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078006467&doi=10.1016%2fj.beha.2020.101143&partnerID=40&md5=0eda4396efc7203eaa425008f7d44ac1
Notes: Review -- Export Date: 1 April 2020 -- Source: Scopus
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MSK Authors
  1. Alexander Meyer Lesokhin
    363 Lesokhin
  2. Kitsada Wudhikarn
    15 Wudhikarn
  3. Beatriz Wills Sanin
    16 Wills Sanin
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