Immunophenotypic analysis of lymphocytes and myeloma cells in patients with multiple myeloma Journal Article

  

Authors:	Shimazaki, C.; Fried, J.; Perez, A. G.; Scheinberg, D. A.; Atzpodien, J.; Wang, C. Y.; Wisniewolski, R.; Clarkson, B. D.
Article Title:	Immunophenotypic analysis of lymphocytes and myeloma cells in patients with multiple myeloma
Abstract:	The immunological phenotypes of lymphocytes and myeloma cells in 48 patients with multiple myeloma (MM) were analyzed using a panel of monoclonal antibodies (mAbs). Myeloma cells were positive for OKTIO, BL3, PCA1 and BA2. In afew cases, they were also positive for the B cell-associated antigens J5, B1 and 12. Eight of 48 cases had more than 15% J5-positive lymphocytes, and some lymphocytes in MM expressed plasma cell-associated antigens (PCA1, BL3, OKTIO), suggesting a possible clonal involvement. These observations demonstrate the heterogeneity of surface antigen expression of myeloma cells and suggest that BL3, PCA1, BA2 and J5 may be useful mAbs for purging myeloma cells from bone marrow for autologous transplantation. © 1990 S. Karger AG, Basel.
Keywords:	clinical article; flow cytometry; t-lymphocytes; phenotype; bone marrow cells; multiple myeloma; b-lymphocytes; monoclonal antibodies; monoclonal antibody; plasma cell; antibodies, monoclonal; immunophenotyping; radioisotope; lymphocytes; plasma cells; antigens, surface; autotransplantation; immunophenotype; human; priority journal; article; support, u.s. gov't, p.h.s.; leukemia, plasmacytic
Journal Title:	Acta Haematologica
Volume:	83
Issue:	3
ISSN:	0001-5792
Publisher:	S. Karger AG
Date Published:	1990-01-01
Start Page:	123
End Page:	129
Language:	English
DOI:	10.1159/000205187
PUBMED:	2109450
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025356073&doi=10.1159%2f000205187&partnerID=40&md5=24678ac9be6d967a218734858cd1fca2
Notes:	Article -- Source: Scopus

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