Consensus guidelines for the definition, detection and interpretation of immunogenic cell death Guidelines

   


Authors: Galluzzi, L.; Vitale, I.; Warren, S.; Adjemian, S.; Agostinis, P.; Martinez, A. B.; Chan, T. A.; Coukos, G.; Demaria, S.; Deutsch, E.; Draganov, D.; Edelson, R. L.; Formenti, S. C.; Fucikova, J.; Gabriele, L.; Gaipl, U. S.; Gameiro, S. R.; Garg, A. D.; Golden, E.; Han, J.; Harrington, K. J.; Hemminki, A.; Hodge, J. W.; Hossain, D. M. S.; Illidge, T.; Karin, M.; Kaufman, H. L.; Kepp, O.; Kroemer, G.; Lasarte, J. J.; Loi, S.; Lotze, M. T.; Manic, G.; Merghoub, T.; Melcher, A. A.; Mossman, K. L.; Prosper, F.; Rekdal, Ø.; Rescigno, M.; Riganti, C.; Sistigu, A.; Smyth, M. J.; Spisek, R.; Stagg, J.; Strauss, B. E.; Tang, D.; Tatsuno, K.; van Gool, S. W.; Vandenabeele, P.; Yamazaki, T.; Zamarin, D.; Zitvogel, L.; Cesano, A.; Marincola, F. M.
Title: Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Abstract: Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation. © 2020 Author(s).
Keywords: review; consensus; practice guideline; in vivo study; in vitro study; oncology; immunology; molecular biology; adaptive immunity; immunogenic cell death
Journal Title: Journal for ImmunoTherapy of Cancer
Volume: 8
ISSN: 2051-1426
Publisher: Biomed Central Ltd  
Date Published: 2020-03-09
Start Page: e000337
Language: English
DOI: 10.1136/jitc-2019-000337
PUBMED: 32209603
PROVIDER: scopus
PMCID: PMC7064135
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081610705&doi=10.1136%2fjitc-2019-000337&partnerID=40&md5=771ef37562e02dee4b34492d9fc52205
Notes: Review -- Export Date: 1 April 2020 -- Source: Scopus
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MSK Authors
  1. Timothy Chan
    317 Chan
  2. Taha Merghoub
    364 Merghoub
  3. Dmitriy Zamarin
    201 Zamarin
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