Identification of gamma heavy chain disease using MALDI-TOF mass spectrometry Journal Article
| Authors: | Thoren, K. L.; Eveillard, M.; Chan, P.; Doddi, S.; Cho, S.; Murata, K. |
| Article Title: | Identification of gamma heavy chain disease using MALDI-TOF mass spectrometry |
| Abstract: | We describe the use of MALDI-TOF mass spectrometry in the analysis of a suspected case of gamma heavy chain disease. The patient had an abnormal serum immunofixation result where a monoclonal gamma heavy chain band was present without a corresponding light chain. Analysis by MALDI-TOF mass spectrometry revealed large peaks in the spectrum following IgG-specific purification. The m/z values of the peaks were outside the expected range for normal heavy chains or light chains. Corresponding peaks were not present in mass spectra of the kappa- or lambda-specific purifications. MALDI-TOF MS confirmed the presence of a truncated heavy chain without associated light chains. This case report demonstrates the value of mass spectrometry in interpreting challenging cases such as the identification of heavy chain disease. © 2019 The Canadian Society of Clinical Chemists |
| Keywords: | maldi-tof mass spectrometry; monoclonal immunoglobulin; heavy chain disease |
| Journal Title: | Clinical Biochemistry |
| Volume: | 77 |
| ISSN: | 0009-9120 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-03-01 |
| Start Page: | 57 |
| End Page: | 61 |
| Language: | English |
| DOI: | 10.1016/j.clinbiochem.2019.12.010 |
| PUBMED: | 31884198 |
| PROVIDER: | scopus |
| PMCID: | PMC7046309 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 March 2020 -- Source: Scopus |
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