Immune checkpoint inhibitors: A narrative review of considerations for the anaesthesiologist Review
| Authors: | Lewis, A. L.; Chaft, J.; Girotra, M.; Fischer, G. W. |
| Review Title: | Immune checkpoint inhibitors: A narrative review of considerations for the anaesthesiologist |
| Abstract: | Immunotherapy has revolutionised the treatment of oncologic malignancies. Immune checkpoint inhibitors represent a new class of immunotherapy drugs. Although these drugs show promise, they are associated with immune-related adverse reactions. An increasing number of patients who undergo surgery will have had treatment with immune checkpoint inhibitors. In this narrative review article, we discuss their mechanism of action, therapeutic effects, pertinent toxicities, and address specific perioperative considerations for patients treated with immune checkpoint inhibitors. © 2019 British Journal of Anaesthesia |
| Keywords: | unclassified drug; review; drug efficacy; drug safety; nonhuman; preoperative evaluation; cancer immunotherapy; immune system; lung toxicity; gastrointestinal toxicity; immunotherapy; drug mechanism; cardiotoxicity; complications; tumor immunity; endocrine disease; molecularly targeted therapy; cancer immunology; adverse events; side effects; immune checkpoint inhibitor; cancer; human; priority journal; perioperative management; anesthesiologist; anaesthesia; immune checkpoint inhibitors; malignant neoplasm; immunological antineoplastic agent |
| Journal Title: | British Journal of Anaesthesia |
| Volume: | 124 |
| Issue: | 3 |
| ISSN: | 0007-0912 |
| Publisher: | Oxford University Press |
| Date Published: | 2020-03-01 |
| Start Page: | 251 |
| End Page: | 260 |
| Language: | English |
| DOI: | 10.1016/j.bja.2019.11.034 |
| PUBMED: | 32007241 |
| PROVIDER: | scopus |
| PMCID: | PMC7890563 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 March 2020 -- Source: Scopus |
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